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10.1007/s10787-020-00690-x 37 HosnedlovaB.KepinskaM.SkalickovaS.FernandezC.Ruttkay-NedeckyB.PengQ.et al (2018)

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Off-target gene silencing remains a concern, since siRNAs with partial complementarity might inadvertently downregulate non-target mRNAs, while endogenous siRNAs processed by Dicer and RISC may exhibit less susceptibility to these inaccuracies