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Description

NNMT normally burns through NAD+ precursors as a kind of metabolic "bleed." Block the bleed, and MOTS-C's expanded mitochondrial activity has more substrate to work with

Michalec K, Mysiorek C, Kuntz M, Brzowski V, Szczepankiewicz AA, Wilczyski GM, et al

Cancer 27 CawleyP.WilkinsonI.RossR

Molinaro et al., 2020)

Further investigation into its involvement in lipid droplet degradation, lipophagy, and circadian regulation is needed to fully define its role within the hepatic lipid metabolic network