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Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4)

Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance

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[59] Studies have shown that children with NF1 are particularly prone to being affected by conditions such as Attention Deficit Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD), as well as psychological disorders such as anxiety or depression, highlighting the importance of multidisciplinary evaluation and care for these patients

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