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No peer-reviewed human clinical trial data on 5-Amino-1MQ efficacy or safety appears to be available in published literature, representing a significant evidence gap

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

This can be due to having low levels of intrinsic factor in the digestive system, having a digestive condition, or following a plant-based diet