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Smart responsive hydrogels overcome this limitation by integrating sensing-response-output functionality, achieved through molecular elements such as dynamic covalent/non-covalent bonds, enzyme-substrate peptides, and external field-responsive units, or gene circuits responsive to specific pathological cues, including pH changes, ROS levels, MMP concentrations, and mechanical stress

J Huntingtons Dis 10:423434 Medina A, Mahjoub Y, Shaver L, Pringsheim T (2022) Prevalence and incidence of Huntingtons disease: an updated systematic review and meta-analysis

PubMed Maurizi AR, Menduni M, Del Toro R, et al

These regulatory sequences can include one or more of the following: an enhancer, a promoter, a signal peptide sequence, an intron and/or a polyadenylation sequence

Fecal zonulin is elevated in Crohns disease and in cigarette smokers