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Smaller antibody formats (scFv, Fab fragments, nanobodies) demonstrate improved tissue penetration, albeit with faster clearance (108)

Journal of Biological Chemistry, 278 (41), 40050-40056

Natural killer cells, inhibiting tumour growth in preclinical CCA mouse models 111 and described to be altered in natural killer immunoglobulin-like receptors and HLA gene loci in patients 112 , hold promise in CCA cell-based therapy

Hence, holistic molecular insights are urgently needed to help develop scientifically sound strategies, through foods, therapeutics, and lifestyle, to alleviate age-related diseases and achieve healthy aging