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The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohns disease

In one study, folate and pyridoxal 5-phosphate, the active form of vitamin B6, were deficient in 37% and 20% of adult celiac patients, respectively, who had been on a gluten-free diet for 10 years and who exhibited biopsy-proven recovery