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Labial Macules: Dark Spots on the Lip Dermatology Advisor Happy Wednesday! In this video, a patient's labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules' are flat and asymmetrical with a tan brown to black Oral Melanotic Macule: Symptoms and Treatment Skinsight Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Venous Lake of Lip and Lip Freckle Removal with Iridex Laser
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