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PMCID: PMC9124646

Nasal administration may actually require higher quality standards since contamination would contact sensitive nasal mucosa rather than subcutaneous tissue that handles minor contamination more readily

Endothelial ion transporters, including the Na-H and Na-K-Cl cotransporter, become dysregulated upon neuronal injury, resulting in an imbalance of ionic gradients and cytotoxic edema that contribute to secondary neuronal damage (Pinheiro et al., 2016)

One possibility to differentiate these eNOS uncoupling related vs

Parasites, Lyme, EBV and co-infections have been shown to damage gut nerves, trigger autoimmune attacks on nerve cells, suppress vagus nerve functioning and cause chronic inflammation