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Cancer Lett 336:149157

Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation

A meta-analysis published in 2023 that included this trial and four other treatment trials conducted since that time concluded that duloxetine is only associated with a modest trend toward pain reduction and that this is accompanied by a similar trend in increased adverse events, suggesting a need for additional well-designed trials to support its continued use in this setting (Chow 2023)