is glutathione an isomerase S-transferase Glutathione and Glutaredoxin—Key Players in

Regulation of cytochrome P450 in cultured human colonic cells

Biochemical studies have not succeeded in identifying conclusively the basis of resistance in any type of cell selected with cDDP, but they have defined several mechanisms that can contribute to resistance

Recent evidence shows that disruption of the flux through the pathway has deleterious consequences

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If mitophagy (mitochondrial autophagy) is impaired as can occur due to inflammatory signaling or aging these dysfunctional mitochondria accumulate