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These findings position NRN1 as a potential therapeutic target in autoimmune disorders, where regulation of Treg function is often impaired

This endorphin depletion may explain some of the chronic pain issues that often accompany PTSD, and also supports the caution that opioid treatment for this disorder may in fact worsen the condition, as stated by the aforementioned National Institute of Mental Health report

Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects