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In the atypical pathway, LPS activates caspase-4/5/11, which triggers cell membrane rupture and pyroptosis by cleaving GSDMD (Jin et al., 2023)

This is not systemic anti-inflammation distributed evenly across the body it is targeted suppression of the cells actively driving intestinal pathology

Just note: the data on the benefits and risks of supplementation remains unclear, particularly as it relates to using vitamin D and calcium supplements together