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Another study shows that TMAO can partially activate the inflammatory corpuscles of NLRP3 by inhibiting the SIRT3-SOD2-mtROS signaling pathway of apolipoprotein E (ApoE) / mice, thus promoting vasculitis (Chen et al., 2017)

Effects of carob (Ceratonia siliqua) on sperm quality, testicular structure, testosterone level and oxidative stress in busulfan-induced infertile mice

Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations

96(1):fiz187

Additionally, one may have nutrient deficiencies or yeast overgrowth and a lack of oxalate metabolizing probiotic organisms in their gut (18, 19)