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The structural change ( Figure 7E ) could potentially hinder the transamination reaction, because the loop movement might bring the -amino group of PMP into closer proximity to other amino-acid side groups, such as His192, promoting the hydrogen bond formation that may influence the reactivity of PMP with GSA

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Their combined presence allows investigators to explore how signaling pathways related to matrix organization, vascular adaptation, cellular movement, and structural maintenance may interact

Related to inflammation, the NF-B signaling pathway is also activated in obesity and is responsible for the production of pro-inflammatory cytokines such as TNF- that induce insulin resistance (139)

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