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And, at any rate, this should only be determined under a properly supervised clinical trial

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Here's where this gets tricky

The following things can cause anaemia Pernicious anaemia Conditions that affect the stomach Surgery to remove all or part of the stomach (gastrectomy) Conditions that affect the intestines e.g crohns disease, Chronic gastritis (an autoimmune condition where the body attacks its own tissues) Lack of vitamins in your diet (Strict vegetarianism) Medicines (a doctor would monitor this with regular blood test to inform patient of B12 levels) Prophylaxis of macrocytic anaemia associated with vitamin B12 The below is recommended for diet related B12 deficiency

They are generally well-tolerated when used as directed under medical supervision, but you should understand what to expect