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The lowest level, the level of the cell, comprises the hallmark neuronal protein aggregates , which may be identified by circulating biomarkers and are typically addressed with targeted, suppressive approaches [25, 26]

Chapter 18 - tackling lung cancer drug resistance using integrated drug-repurposing strategy

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doi: 10.1161/ATVBAHA.120.314515 28 BrueggemanJ

Treatment effect estimation For each tested drug, we estimated drug treatment effect for each balanced trial by calculating the hazard ratio (HR) using a Cox proportional hazard model 102 , comparing the risk to develop a specific outcome between the treated and control groups