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It targets melanin synthesis without significantly affecting melanocyte cells themselves meaning it's working on the pigment-production pathway, not causing cell damage

Their functional enrichment analyses linked these genes to mRNA metabolic processes, immune cell regulation, and RNA transport pathways, confirming their potential role in OA pathogenesis and immune-mediated joint degradation (Huo et al., 2025)

With the LH surge, there is shedding of the basement membrane and invasion of macrophages and neutrophils, which release a lot of ROS (188)

Britton C, McCormick FM, Renfrew MJ, Wade A, King SE

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