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Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis

Hypoxia-sensitive pathways in intestinal inflammation

With direct hGH injections, especially at high doses, theres a risk of excessively elevated GH/IGF-1 levels, which may lead to side effects like joint pain, edema, insulin resistance, or carpal tunnel syndrome

A large quantity (85~90%) of CD38 high NK cells are killed

The aqueous extract of Acer palmatum Thumb