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The drug was been approved since 1959 and is used for the following indications: References Mechanism of Action 1,2 Phentermine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation

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Increased mitochondrial import of malate may enhance complex I activity, leading to elevated mitochondrial ATP production

Fatty acids trigger mitochondrion-dependent necrosis