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The diurnal fluctuation of melatonin production and its multifunctional biological effects enable the adjustment of diverse physiological functions, such as the sleepwake cycle, hormone secretion (e.g., cortisol and leptin), anabolic and catabolic reactions, and reductions in body temperature and blood pressure, in response to the lightdark cycle

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doi: 10.1007/s11064-016-2099-2 59