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The study of Meguid et al., involved 30 healthy children and 30 children affected by autism (18 males, 12 females), aged 311 years, all diagnosed with DSM-V and CARS, with no reported medical comorbidities and in good physical health

37 reported decreased k cat app and increased K m app (GSSCys) values upon replacement of Lys19 in a single cysteine mutant of human Grx1

One of the key mechanisms through which nicotinamide may exert these protective effects is by restoring the levels of nicotinamide adenine dinucleotide (NAD+), which is critical for mitochondrial metabolism and energy production

doi: 10.1136/bjo.86.12.1369

Funding The fund for this research work was provided by the grant from Indian Council of Medical Research (ICMR F.No