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investigated the S100A9-RAGE-NF-kB-JunB pathway by using intracardiac injection of a breast cancer cell line to establish BM in a mouse model [14]

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14 However, Hemils findings suggest further research on vitamin C and heart failure is warranted, particularly in those with low LVEF together with low vitamin C intake or low plasma levels, in addition to comparisons between different dosages and different routes of administration