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Repression of the antioxidant NRF2 pathway in premature aging

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Clinically, plasma malondialdehyde (MDA)a byproduct of lipid peroxidationserving as a biomarker of oxidative stress severity, with elevated levels correlating with accelerated lung function decline in COPD patients

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SiO(2)-induced ferroptosis in macrophages promotes the development of pulmonary fibrosis in silicosis models