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It has been demonstrated that NRF2 over-activation may be therapeutically beneficial for ameliorating RA owing to its anti-inflammatory and anti-oxidative activity associated with limiting cytokine production, cartilage-matrix degradation, and bone resorption 63

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US20070232692, US20120101154, the therapeutic agents described herein may be formulated with and/or administered with agents that modulate the activity and/or levels of succinate the therapeutic agents described herein may be formulated with and/or administered with agents that modulate the activity and/or levels of TNF alpha receptor, TRADD, NFNB, STAT3, RhoA, FLIP, FADD, bilirubin, transaminases, and/or caspases