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induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells

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(Stockler-Pinto et al ., 2009) Unlike primary antioxidants that can cope with high volumes of free radicals, the secondary (non-enzymatic) antioxidants, such as vitamins, minerals and polyphenols, which are sourced via the diet, have a more limited capacity to quench free radicals

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Additionally, the molecular chaperone heat shock protein family A member 5 (HSPA5) interacts with GPX4 and blocks GPX4 degradation, thus decreasing the sensitivity of cells to ferroptosis[68]