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Given its nutrient richness and biofunctional diversity, RJ is widely used as a dietary supplement and for antibacterial and anti-inflammatory treatments ( 4.6.2 Mechanism of action in dry eye disease RJ exhibits natural antioxidative characteristics, significantly reducing ROS and nitric oxide production in macrophages and boosting activities of antioxidant enzymes like SOD and glutathione ( RJs anti-inflammatory effects are mediated through its fatty acid analogs, including 10-hydroxy-2-decanoic acid, 10-hydroxy decanoic acid, and sebacic acid, which effectively inhibit the release of pro-inflammatory cytokines and other inflammatory mediators (Yang et al., 2018b)

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However, hepatic SIRT6 overexpression in mice has been found to reverse ethanol-induced damage by enhancing transcriptional the induction of Mt1 and Mt2 genes and improving the hepatic defense system against alcohol toxicity [95]

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