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Collectively, probiotics efficacy in enhancing immunotherapy hinges on three core principles: (1) strain-specific metabolite production (e.g., L

PEX2 can ubiquitinate PEX5, thereby activating NBR1-dependent pexophagy (Sargent et al., 2016)

Further, -LA can provide additional antioxidant effects by recycling both vitamin C and vitamin E (Coombes et al., 2000)

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Another enzyme, Catechol-O-methyltransferase (COMT), transfers a methyl group to catechol compounds, thereby producing S-adenosyl homocysteine (SAH), a homocysteine precursor