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Some studies have confirmed that increased blood levels of lead may disturb brain functions, termed encephalopathy

Cell 166 (1), 2145

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Pachman D.R., Dockter T., Zekan P.J., Fruth B., Ruddy K.J., Ta L.E., Lafky J.M., Dentchev T., Le-Lindqwister N.A., Sikov W.M., Staff N., Beutler A.S., Loprinzi C.L

doi: 10.1016/j.cell.2012.02.044, 39

Even though it is now considered a third branch of the autonomic nervous system (ANS), the ENS has been referred to as the second brain [171], based on its size, complexity, and similarity in neurotransmitters and signaling molecules with the brain [171]