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For example, etesevimab, an anti-SARS-CoV-2 mAb developed by Eli Lilly that has received an EUA for COVID-19, has been engineered to lack FcRI and FcRII-binding activity with L234A and L235A mutations (the LALA modification) 74 in the Fc domain to reduce safety concerns over the potential to exacerbate disease through ADE mechanisms 75

Immediate medical attention is required

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The best way to prevent deficiency is to consume enough vitamin B12-rich foods or take a supplement

However, these side effects are usually mild and resolve quickly