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10.1093/jnci/djy134 128 JiangM.IncarnatoD.ModdermanR.LazaroA

Individuals at baseline with schizophrenia were younger than controls ( P = 0.04)

STAT3 then translocates to the nucleus to activate the expression of pro-inflammatory genes (Moshapa et al., 2019)

This creates a well-documented vicious cycle: stress increases histamine release, histamine amplifies nervous system reactivity (histamine H3 receptors modulate neurotransmitter release, and elevated brain histamine disrupts sleep, worsens anxiety, and heightens stress perception), which in turn drives more stress and further mast cell activation

By maintaining high levels of glutathione and Vitamin C, you create an "antioxidant shield" that protects your existing collagen from being broken down prematurely