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This review explores gut dysbiosis across a broad spectrum of conditions, including neurodegenerative diseases (e.g., AD, PD, ALS), psychiatric disorders (e.g., MDD, BD, PTSD, anxiety), autoimmune syndromes (e.g., MS), and neuroinflammatory or toxic exposures (e.g., radiation, xenobiotics)

For instance, preexisting neutralizing antibodies (NAbs) in the body can neutralize and precipitate AAV virus, activation of Toll-like receptors (TLRs) can trigger innate immunity, and AAV capsid proteins or nucleic acids can stimulate the production of antibodies against themselves

The MTX group showed significant elevations in hepatic ATF4 and GRP78 versus the CTRL group

As ATP becomes available again, it can be redirected to the brain, muscles, and autonomic nervous system

GSH is also consumed through glutathione S-transferase-catalyzed conjugation and reversible protein S-glutathionylation