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Additionally, increased levels of iron in specific brain regions further augment neuronal vulnerability to oxidative stress (29)

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Rapid photodynamics of vitamin B6 coenzyme pyridoxal 5-phosphate and its Schiff bases in solution

doi: 10.1016/j.joca.2021.06.013 21 MobasheriABondyCAMoleyKMendesAFRosaSCRichardsonSet al

By further elucidating the pathogenic mechanism by which hepatic iron accumulation triggers ferroptosis through the c-Myc-Acsl4 regulatory axis, thereby accelerating the progression of metabolic-associated steatohepatitis (MASH), our research team identified a novel iron chelator, FOT1 (FerroTerminator1, formerly known as CN128), through drug screening, which can prevent and treat the onset and progression of MASH disease [117]