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However, the prodrug technology still faces three key challenges in achieving precise treatment: off-target activation risks (such as premature release due to liver metabolism), tumor microenvironment [8] heterogeneity (such as the uneven distribution of hypoxia levels within the tumor, which hinders the effective release of hypoxia-activated prodrugs [9] and leads to poor treatment efficacy [3]), and insufficient temporal and spatial control accuracy

McSweeney, M

AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics

Wheeler CJ

Depletion of CAFs from the culture system reduced the expression of stemness markers OCT4/SOX2/NANOG and the anchor-independent capacity in CSCs, whereas it increased the expression of differentiation markers such as adenocarcinoma and squamous carcinoma markers (thyroid transcription factor 1, CK7, CK20, p63, and keratin 5/6)