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This paper was published in Neural Regeneration Research (Vol 9, No 10, 2014)

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Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis

Inhibition of ERR with XCT790 treatment can increase the expression of CPT1A, further promoting lipid metabolism ( Adiponectin Adiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health ( via the AMPK-ACC-CPT1A pathway ( Metabolite regulation of CPT1A Long chain fatty acid (LCFA) LCFA is a substrate for CPT1A and one natural ligand of PPAR ( via activating PPAR ( Malonyl-CoA Malonyl-CoA is produced by acetyl-CoA carboxylase2 (ACC2) during fatty acid synthesis, and is a natural inhibitor of CPT1A