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In addition to the CHOP signaling pathway, eIF2, a direct substrate of the PERK pathway, has also been implicated in immune responses in IBD (93)

As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

This effect is also dose-dependent [84]

Zhang F, Li ZL, Xu XM, Hu Y, Yao JH, Xu W, Jing HR, Wang S, Ning SL, Tian XF (2015) Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury

By consulting your healthcare provider, you can receive personalized guidance that considers the specific nuances of pregnancy and how glutathione supplementation may impact this crucial stage of life