Sergey Terushkin, MD, FACS Key Takeaways Turn on the news or scroll through TikTok, and you will see it: Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro, Zepbound) are being hailed as the end of obesity. And in many ways, they are
Subsequently, cDNA was generated via reverse transcription employing the RevertAid First Strand cDNA Synthesis Kit (Fermentas), adhering strictly to the protocol provided by the manufacturer
Karim Y, Siddique AE, Hossen F, Rahman M, Mondal V, Banna HU, et al
Reactive oxygen species (ROS), including hydroxyl radicals (OH - ), hydrogen peroxide (H 2 O 2 ), superoxide anions (O 2 ), and lipid peroxides, are molecules highly reactive because of the presence of unpaired electrons ( The oxidant/antioxidant cell balance can by evaluated by several plasma and/or erythrocyte markers ( Oxidative Stress in GH Thyrotoxicosis is a hypermetabolic state characterized by high consumption of intracellular ATP and oxygen, and by dysfunction of the mitochondrial respiratory chain, which leads to saturation of the physiological antioxidant systems, resulting in an uncontrolled production of ROS in peripheral tissues as well as in the thyroid ( in vitro studies have shown that exposure of thyroid cell to H 2 O 2 , particularly when made selenium-deficient, induces DNA double strand breaks, apoptosis, necrosis and mutagenesis ( Animal Studies Studies in animal models suggest that thyrotoxicosis, induced by the administration of triiodothyronine (T3) or thyroxine (T4), promotes oxidative stress as well as the response of the physiological antioxidant machinery ( Human Studies The most relevant clinical studies on the role of oxidative stress in thyroid diseases have been performed in GH patients, either with uncontrolled hyperthyroidism, or after restoration of euthyroidism with antithyroid drugs (ATD) or radioiodine (34, 35)
Transl Res Methods Major Depress Disord
