In intact skin without a penetration enhancer (such as ethosomes, liposomes, or hyaluronic acid conjugation), multiple ex vivo tape-stripping studies show that most topically applied GHK-Cu accumulates in the stratum corneum and upper viable epidermis, not in the dermis where fibroblasts live

The signs and symptoms of B12 deficiency that indicate you may benefit from vitamin B12 injections include: chronic fatigue, lethargy and weakness Muscle aches, joint pain and trouble exercising Poor memory, inability to concentrate and other cognitive problems associated with aging Mood changes, like increased depression and anxiety, or signs of nervousness like rapid heartbeats/palpitations Poor dental health, including bleeding gums and mouth sores Shortness of breath and feeling dizzy Poor appetite or digestive problems, like constipation, nausea, diarrhea or cramping Sometimes greater risk for problems like cardiovascular complications or even cancer (due to a rise in homocysteine levels) Why might you be low in vitamin B12, even if you eat a relatively healthy diet
rat dose: 2.57 mg/kg/d), 100 mg/d paraxanthine (PXN HIGH
GHK-Cu is sensitive to pH, light, oxygen and heat
It is possible that interactions could occur with certain medications, including insulin, blood thinners, and chemotherapy