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The observed tumor uptake was higher than that of the previously reported PEG-coated Au nanorods (~7.1% ID/g) 27 , Au NPs (~3% ID/g) 29,37 , small Au NCs (~2.33.2% ID/g) 47

Keywords: arsenic trioxide, acute promyelocytic leukemia, PML-RAR, drug resistance, drug metabolism Highlights 1.Arsenic trioxide achieves curative efficacy in acute promyelocytic leukemia by targeting and degrading the PML-RAR fusion oncoprotein