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doi: 10.1172/JCI178722 2 MengXLayhadiJAKeaneSTCartwrightNJKDurhamSRShamjiMH

The mechanism of NAC-mediated Notch2 reduction was elucidated by promoting Notch2 degradation through Itch-dependent lysosome pathway

Neuronal Signaling 5:NS20210008

Secondary hyperuricemia is also seen in individuals with myeloproliferative disorders undergoing therapy where there is excess cellular turnover (cell lysis leads to an accumulation of nucleotides) or in cases of Von Gierke disease or fructose intolerance, which increases substrate for PRPP synthesis