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These nanoformulations (e.g., liposomes, polymeric NPs) not only enhance pharmacokinetics but also actively modulate the tumor microenvironment (TME) by inhibiting myeloid-derived suppressor cells (MDSCs) and cancer-associated mesenchymal stromal cells (MSCs) [76, 77]

Although the promising results derived from animal model studies are noteworthy, it is crucial to acknowledge that these outcomes may not necessarily be extrapolated seamlessly to humans due to inherent biological differences

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