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Non-catalytic enzymemetabolite interactions remain challenging to study, with the consequence that we still lack a systems- or network-wide understanding of the role of intrinsic small molecule enzyme activators

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Cells were then treated with 5, 10 and 20 M CUR or Nano-CUR and their vehicle controls (DMSO and PLGA NPs, respectively) for 6 hrs

277 Abnormal NAD + metabolism in the pathophysiological condition Given the essential regulatory role of NAD + in fundamental physiologies, NAD + metabolic abnormalities contribute to the pathophysiology of various diseases, such as infection, cancers, metabolic diseases, aging and age-associated neurodegeneration disorders

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