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4.2 Healthy-tissue antioxidant shielding and the antioxidant paradox Many standard therapies cause systemic oxidative injury (e.g., cardiotoxicity from anthracyclines), prompting antioxidant shielding strategies ( 4.3 Safety implications of dual redox programming The same formulation feature that is attractive for tumor sensitization, namely, prolonged intracellular residence or stimulus-linked release, can magnify liability when exposure occurs in non-target tissues

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To further test the crucial role of GSH in the acute phase of colitis, we analyzed the effect of NAC, a GSH precursor, on mucosal GSH levels in relation with the TNBS-induced colitis

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