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The Treg subpopulations observed in mouse tumor models exhibited a high degree of similarity to those found in human tumors responsive to anti-PD-1 therapy (123)

Renal function, however, is critical for acamprosate use, as it is renally cleared

L-lactate, the predominant form in the human body and brain, is involved in various biological processes, such as regulating energy production and metabolic pathways [13, 14]

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Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways