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As discovered more recently by Zhangs group, NRF2 can also be negatively regulated through the E3 ubiquitin-protein ligase synoviolin (HRD1), recently associated with the ER stress produced by misfolded protein accumulation

Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.J OculPharmacolTher

doi: 10.3390/ijms21124390 46 GuilhenC.CharbonnelN.ParisotN.GueguenN.IltisA.ForestierC.et al

Several reports have shown that HGF fauns dimers and/or multimers, which are arranged in a head-to-tail orientation, prior to its interaction with Met (Gherardi et al., 2006)