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Each episode jolts the body into wakefulness, fragmenting sleep and depriving sufferers of the deeper stages essential for restoration

2 The figure shows the molecular evolution of obesity drugs a

doi: 10.1097/HM9.0000000000000100 421 ZhouHLiJSunFWangFLiMDongYet al

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Results Whole-body deletion of Keap1 improves insulin sensitivity and upregulates NQO1 expression To investigate the role of NRF2 hyperactivation in metabolism, we generated a transgenic mouse strain exhibiting whole-body inducible knockout of the Keap1 gene, by crossing Keap1 floxed mice 30 with mice expressing Cre recombinase under the control of the CAG promoter (Keap1-KO