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In the clinical conditions presented in the review, increased intestinal permeability has been demonstrated, but the central question of whether the barrier dysfunction is a primary event in the pathophysiology or a consequence of the disease is still not resolved in most diseases

Adults (aged between 19 to 64) need around 1.5 microgram a day of vitamin B12

Despite these promising findings, more extensive clinical trials are needed to investigate long-term efficacy and potential therapeutic applications (1)

B12 is also necessary for proper red blood cell (RBC) formation, neurological and brain function and protein and fat metabolism

However, supplements provide much higher doses than food alone