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In an obese environment, many B2 cells are recruited into VAT through the action of the chemokine leukotriene B4 (LTB4) and its receptor LTB4R1, leading to tissue inflammation and the development of insulin resistance (163) ( Figure 3 )

Differences between two and multiple populations were assessed using the two-tailed Students t- test and one-way ANOVA with Tukeys post-hoc test respectively