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Vitamin B12 deficiency can lead to a range of symptoms including fatigue, weakness, pale skin, shortness of breath, numbness or tingling in the hands and feet, and cognitive issues, such as memory loss or difficulty concentrating

When you start tirzepatide on top of an already marginal B12 status, the dramatic reduction in food intake can push levels from borderline into genuinely deficient territory relatively quickly

Older adults, for instance, often have reduced stomach acid production, which can make it challenging to absorb B12 from food

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That's made it interesting as a possible remedy for menopause symptoms such as depression, bone loss, and sexual problems