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(b) its ability to bind to numerous specific GPCRs, which triggers and initiates intracellular responses ( via the GLA and gutbrain axis ( The effects of butyrate on the gut Non-alcoholic fatty liver disease development and progression may be influenced by overnutrition, genetic predisposition and changes in gut microbiota and intestinal barrier functions, which may develop into elevated endotoxin levels and increased permeation of bacterial endotoxins ( Both in vitro and in vivo studies suggest that butyrate affects intestinal homeostasis by improving intestinal integrity and modulating tight junction (TJ) proteins ( Treatment with butyrate may stabilise the disrupted TJs structure

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FIGURE 1 Over the past three decades, drug development based on the concept of single-target blockadesuch as anti-endotoxin antibodies, specific TNF- antagonists, or single anticoagulant agentshas repeatedly failed in clinical trials (Marshall, 2014)